TP53 OVEREXPRESSION Detail (hg19) (TP53)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr17:7,571,720-7,590,856 |
| hg38 | chr17:7,668,402-7,687,538 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| ovarian cancer | B |
Prognostic
|
Supports
|
Poor Outcome | Somatic | 3 | 11595686 | Detail | |
| stomach cancer | Cisplatin,Etoposide,Mitomycin | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 14514923 | Detail |
| ovarian cancer | Cisplatin,Carboplatin | B |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 11595686 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| p53 overexpression (>10% positive stained nuclei) was found in 110 cases from a 178 patient cohort w... | CIViC Evidence | Detail |
| In a Phase II trial of 25 patients with metastaic gastric cancer, patients received preoperative hig... | CIViC Evidence | Detail |
| In a study involving patients with invasive ovarian carcinoma who had undergone surgery, a subset of... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- TP53
- Genome
- hg19
- Position
- chr17:7,571,720-7,590,856
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000269305.4
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/1306
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